Quantification of water exchange across the blood-brain barrier using noncontrast MR fingerprinting
Magn Reson Med 92(4):1392-1403
Why it matters: Noncontrast MR fingerprinting highlights BBB exchange as a quantitative biomarker.
Neuroimaging
Quantitative MRI methods for neuroscience studies, including AI-enabled stratification.
Bioxydyn is experienced in the deployment of quantitative MRI methods for neuroscience in conditions including multiple sclerosis, neurodevelopmental conditions, dementia, and neuro-oncology. Our collaboration with Queen Square Analytics enables advanced AI methods for patient stratification with a focus on multiple sclerosis and Alzheimer's disease.
Bioxydyn provides commonly used techniques such as atrophy measurements and diffusion MRI measurements. We also provide more complex quantitative methods, including dynamic contrast-enhanced MRI (DCE-MRI) measurements of subtle blood-brain barrier dysfunction, arterial spin labelling (ASL), MR spectroscopy, and relaxometry. These measurements can be used to interrogate physiological phenomena, metabolism, drug effects, and mechanism of action in a wide range of neurological conditions.
Our neuroimaging workflows combine protocol design, site qualification, quality control, and audited analysis to deliver repeatable biomarkers across sites and scanners. The result is a defensible dataset that supports confident decisions in neurological development programs.
Neuroimaging publications
Peer-reviewed neuroimaging studies supporting quantitative MRI, perfusion, and AI-enabled stratification.
5 publications
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Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications
Magn Reson Med 92(2):469-495
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Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI
Magn Reson Med 91(6):2579-2596
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An efficient semi-supervised quality control system trained using physics-based MRI artefact generators and adversarial training
Med Image Anal 91:103033
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Blood-brain barrier water exchange measurements using contrast-enhanced ASL
NMR Biomed 36(11):e5009